Drugstores sell 1) moleskin, or 2) "tuff-strips" bandaids - LARGE - to cover the blister area. DON'T intentionally pop a blister because it opens you up to infection and it's nature's way of trying to protect the area. Put a cover on that spot before every run for a little while and see if you develop a callus there - you might. I did. Eventually. Alternately, return the shoes, telling the store "they give me blisters and I can't wear them" and get a different pair. Depends on how much you like the shoes. If the sales clerk at the shoe store gives you grief, go right to the manager. Raise a fuss if necessary, but usually running stores want your business. Your repeat business. Which means they have to have you as a satisfied customer.

You could always try a barefoot run. www.barefootrunning.org. I've been enjoying their site immensely lately...