In my experience blisters come and go sometimes. Here are the things I have found to help: 1) Proper shoe and insole fit, Imbalanced insoles can cause blisters on the bottoms of your feet. 2) Good Socks, I am a big smart wool fan. I wear smart wool light hiker crew socks. I find they fit really well, don't sag or bunch. Last a pretty long time and have padding in the right places. 3) I have been using this stuff called Sport Shield by 2Toms. It comes in a powder, Roll-on or pads. I like the roll-on or pads. It works kind of like Pam for your body ... I like it because it doesn't leave anything for sand and dirt to stick to. It can be a little hard to find though. 4) Time - I don't know this but I think the more time you spend on your feet the tougher the skin seems to get. I know that I don't get as many blisters now as I did when I started running. 5) I have also heard hydration may have something to do with it. I would be curious to see if anyone has any facts to back up my last two statements. I have also had better luck with healing if I put Neosporin on a band-aid and keep them covered until all of the inflammation is gone … even at night. Good luck SG

Have you tried with just one pair of socks? I would think that that extra thinkness might cuase additional pressure points.

Fatozzig I've had a lot of problems with blisters in the past, even worse when me feet got wet. I started wearing Wright double layer socks and the problem was solved. I ran 16 miles in the pouring rain and didnt get one blister. Everyones feet are different but you may want to give them a try. Dan

I've never tried this but I'm told using a good quality duct tape over hot spots works well. Just be carefull when removing it. Please help support me my visiting my blog. Comments and suggestions are welcome http://breakhearttrailrunning.blogspot.com/

Things went really well Saturday. The blister from last week is still holding on strong, but I used these http://www.spenco.com/product/606-pressure-pads on my hot spots and they flared only slightly in the three hours I was out there. Stacy - This whole blister thing started with three new changes a number of months ago: I stupidly tried to reduce my callouses , my custom orthotics were resurfaced with leather, and I got new shoes. I've had problems ever since, even though I no longer use the orthotics and I've quit messing with the callouses. I think it's just a matter of them building back up. In the meantime, though, things have been a real pain in the rearend.